The first annual meeting was held June 20, 1922, at the Glendale Lyceum and the first official board elected was President, Mrs. Samuel Taft; Vice-President, Mrs. William Cooper Procter; Secretary, Mrs. Frank Suire; Treasurer, Mrs. Charles Moss. Although Mrs. Alfred Allen and Mrs. McLean Blaire were not on the first board, they were instrumental in assisting in the creation and organization of the group. 

There were ten clubs at the first meeting:
Clifton Garden Club
Garden Club of Cincinnati
Garden Circle of the Cincinnati Woman's Club
Garden Circle of the Wyoming Women's Club
Garden Lovers
Glendale Garden Club
Glendale Garden Crafters
Hartwell Garden Club
Norwood Garden Club
Terrace Park Garden Club

In 2021-2022 Federated Garden Clubs of Cincinnati and Vicinity celebrated its 100th Anniversary. In commemoration a Centennial Celebration Year Autumn Meeting and Founders Tea was held in October, 2021 at the Cincinnati Woman’s Club. In April, 2022 Federated held an NGC Standard Flower Show titled 100 Years of Gardening, Flower Shows, Projects & Friendship at Maple Knoll Village Auditorium. From Garden Club of Ohio, Inc., this flower show won First Place for a standard flower show with more than one club, First Place for the schedule for more than one club, and First Place for the best educational exhibit in a standard flower show for more than one club. A large rosette ribbon was also received for the best standard flower show for near clubs (clubs from the same local area). 

In May, 2022, Federated Garden Clubs of Cincinnati and Vicinity Spring Meeting and Centennial Celebration Luncheon was held at Fairfield Community Arts Center. The first speaker was Dr. Allan Armitage, World renown plantsman, lecturer, author, and Professor Emeritus. The second speaker was Scott Beuerlein, Manager of Botanical Garden Outreach at the Cincinnati Zoo & Botanical Garden, Horticulturist, award winning writer, and speaker.